Spider-Man has one of the best-known rogues galleries in comics. Many of Spider-Man's villains' origins are based in scientific accidents or the misuse of scientific technology, paralleling Spider-Man himself. Likewise, many also have animal-themed costumes or powers. Spider-Man's enemies are some of the best rounded antagonists in comics, with equal emphasis put on both their special abilities and their personalities. Spider-Man also has a wide range of villains: hapless thugs, mad geniuses, crime bosses, and even extraterrestrial monsters. Due to the nature of the shared universe he inhabits, he has also fought many villains more closely associated with other heroes. However, these are not considered Spider-Man's own enemies.

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